grapefruit can get you higher?

[alkatraz]

I was reading in the Vancouver Sun today that Grapefruits have been taken off the menu at Hospitals.

Supposedly the've determined that Grapefruit has something crazy in it that reacts with perscription drugs in your digestive system and makes them 3x more potent. I don't remember the details but a certain amount of perscription drugs you ingest never makes it into your bloodstream and chemists/doctors give you a higher dosage to allow for this amount of "wasted" drugs.

When you eat grapefruits, it reacts with the "wasted" amount and puts it into your bloodstream giving you up to 3x the dosage you would normaly get which has the ability to overdose a patient




So I'm curious if grapefruit has the same effect on non-perscription oral drugs??? (ie: extamacy)

Anyone ever heard or tried this before?

[MC Hammered]

I do know that eating too much grapefruit can cause your blood to become diluted and you will feel a bit lightheaded.

Would it get you any higher if you pop E? Based on the information quoted below it could actually lessen the effect.

Why? MDMA needs an enzyme in the liver to metabolize in order for it to work. If you lack this enzyme, and some people do, you will not get high.

I do not know if grapefuit juice would block an enzyme produced in the liver but you never know. However, drinking the grapefuit juice will give you loads of Vitamin C which is a good anti-oxidant to help protect your brain from the aftereffects of the MDMA trip.

-----------------------------------

Here is some information about this issue -> http://www.pharmacytimes.com/article.cfm?ID=258

Do certain foods have the potential to interact with over-the-counter medications?

Yes, certain foods and beverages can interact with medicines – potentially making them less effective or causing side effects. Changes in a medicine’s effect due to an interaction can be significant, however, there are many individual factors that influence the potential for variations, such as dosage, age, weight, sex and overall health.

Calcium-rich dairy products (such as milk, cheese and ice cream), antacids and vitamins containing iron can all lessen the effectiveness of antibiotics, particularly tetracycline. Mixing any of these with a prescription antibiotic can cause a much slower absorption rate of the antibiotic into the blood stream/body, causing it to have a decreased effect.

Grapefruit juice blocks enzymes that normally metabolize certain drugs, leaving more of the compounds to be absorbed and thus increasing blood levels of the medications. For example, grapefruit juice should not be taken with certain blood pressure-lowering medications, the antihistamine terfenadine and cyclosporine, a drug taken to prevent organ transplant rejection.

[kimmay candy]

^ wow!! MC HAMMARED you just really inpressed me with your wit holy shit! yeah I have heard if your haveing a bad trip on shrooms you should eat and orange or sumthing cirtus because it will lessen your high

[MC Hammered]

With my wit?? What wit? I was being truthful in my reply.

As for a bad trip on shrooms the last thing you want is citrus fruit as the acid will breakdown the remaining mushrooms in your stomach even more and make the trip last longer.

What you want to do is to have something with sugar in it like a can of pop. The sugar will lessen the high and shorten the duration of the trip but you still have to ride it out.

[Joanne]

Originally posted by MC Hammered
Would it get you any higher if you pop E? Based on the information quoted below it could actually lessen the effect.

Why? MDMA needs an enzyme in the liver to metabolize in order for it to work. If you lack this enzyme, and some people do, you will not get high.

winston: I don't believe it would lessen the effect. from what I've heard something in the grapefruit inhibits a certain enzyme mostly found in the liver and intestinal tract that is responsible for METABOLIZING the drugs in your system, NOT the ones for activating them. therefore, there would be an increase of the blood levels of whatever particular drug you are taking, resulting in you perhaps becoming "higher".

however, this is not the case for every single type of drug out there... here's a website if you're interested: http://www.fhma.com/grapefruit.htm

--Joanne :P

[MC Hammered]

I'm no medical expert but I made my comment based on the fact that I read that the enzyme CYP2D6 is required to metabolize the MDMA.

Without this enzyme the MDMA would not have any effect, so a reduced amount would make you less high right? This is assuming that grapefruit juice has an effect on this particular enzyme.

Dancesafe has a page on drug contradictions as well: http://www.dancesafe.org/documents/d...ndications.php

[Locky]

Originally posted by MC Hammered
I'm no medical expert but I made my comment based on the fact that I read that the enzyme CYP2D6 is required to metabolize the MDMA.

Without this enzyme the MDMA would not have any effect, so a reduced amount would make you less high right? This is assuming that grapefruit juice has an effect on this particular enzyme.

Joanne posting under Kevin's account:

I don't believe that's the enzyme... ithe enzyme that grapefruit apparently inhibits is something like cytochrome IP, blah, blah blah or some shit.

--Joanne :P

[alkatraz]

"Well, according to my calculations the CYP2D6 is required to metabolize the MDMA which apparently inhibits the cytochrome..."



wow, you guys are really smart and I feel dumb! :284:
thx for the info!!!


hey crazy rave bus SEAN! do you mind testing out this theory for me? =) I'll pay for the grapefruit :toasted:

[stringbeans]

i always thought vitamin c acted as a catalyst for ecstacy

john
2899131

[MC Hammered]

Vitamin C isn't a catalyst but works as an anti-oxidant.

It protects your brain from damage due to the oxidation of the dopamine, or rather prevents the oxidation of the dopamine, which basically turns the dopamine into compound that resembles bleach.

[Lenny]

Originally posted by stringbeans
i always thought vitamin c acted as a catalyst for ecstacy

john
2899131

You're thinking of 5-HTP

[stringbeans]

^^ no, im not

[Lenny]

are too :moon:

[Joanne]

Originally posted by (LJF)

You're thinking of 5-HTP

5-htp isn't a catalyst for ecstasy. it's a precursor for l-tryptophan and serotonin, which can be used for preloading to lessen the neurotoxic effects of mdma.

:moon:

--Joanne :P

[Tekno_Kid]

A compound found in grapefruit juice (6,7-dihydroxybergamottin) inhibits enzymes that metabolize drugs in humans. Most supplements are not absorbed by the body and merely washed through with other wastes. If you can increase the bioavailability of all the supplements you are taking you will get more bang for your buck, this includes MDMA.

[alkatraz]

you will get more bang for your buck, this includes MDMA.

nice! good to know
thx

[Tekno_Kid]

Originally posted by alkatraz


nice! good to know
thx

no problem! for more info on preloading/reloading, check out:

www.rollinballzcrew.com/preload.shtml

Happy Rollin' :)

Jesse

[Joanne]

A compound found in grapefruit juice (6,7-dihydroxybergamottin) inhibits enzymes that metabolize drugs in humans.

that's still under study.. I don't think scientists are exactly sure if 6,7-dihydroxybergamottin really IS specifically what inhibits those enzymes.

eg. http://www.powernetdesign.com/grapef...1abstract.html

If you can increase the bioavailability of all the supplements you are taking you will get more bang for your buck, this includes MDMA.

but how would you do this?

--Joanne :P

[DefectiveMeme]

I think that drinking grapefruit juice would have a minimal, if any effect when combined with MDMA.

Grapefruit juice has been found to inhibit the CYP-1A2 and CYP-3A4 enzymes - this can be problematic for certain drugs, namely SSRI antidepressents and some heart medications, because it essentially stops the liver from metabolizing these drugs at all and levels become toxic.

MDMA, however, is metabolized mainly by CYP-2D6, as someone mentioned in the above posts. I don't believe Grapefruit juice inhibits this CYP enzyme.

One substance that does slow metabolism of MDMA is DXM. It does not inhibit CYP-2D6 - rather, it is also metabolized by it, so the dual work slows the rate. I would not recommend combining the two though - seriously, the amounts of both MDMA and DXM in your system could both elevate to dangerous levels.

[Crazy Dave]

Originally posted by kimmay candy
^ wow!! MC HAMMARED you just really inpressed me with your wit holy shit! yeah I have heard if your haveing a bad trip on shrooms you should eat and orange or sumthing cirtus because it will lessen your high

Yes I drink grap fruit juice to make me come down on mush rooms, when I have no time to be high... often while working I might eat to much shroomz and then to fucked up for clean up.... but I find this helps me come down fast.

This might not work with every one, so don't bet your brain cells on this one.

[Crazy Dave]

Vitamin c, or any acids in your system will lessen the effects of any alkaloid based drugs in two ways. One is more of the drug brakes down in you stomach, and the other is binding to them in your brain.