E and antidepressants..stories????

gratia · #1 (**permalink**) May 21, 05

ok...so. i am wondering if anyone knows anything about wellbutrin(bupropin) and dyserel(trazodone). cause....well...i am taking them both, very small doses...and i sorta really really really want to take E. cause i haven't in a while and i am going to a party with my friend who will probably pop and i don't wanna be left in the dust. you know? so if any one knows anyone who has had an aweful or life threatening experience please tell me ;)

ps...i know you are all gonna be like..."WTF? are you a freaking idiot? why would you mix perscription drugs with street drugs????" but i am probably gonna do it anyway unless someone tells me it is potentially dangerous, for real, and not just "your a stupid idiot" dangerous. know what i mean. please don't give me the talk just give me facts. thanx

decypher · #2 (**permalink**) May 21, 05

SSRI's have different effects. google it or read up on erowid.org or something.

ebbomega · #3 (**permalink**) May 21, 05

E is always potentially dangerous. Do you have a testing kit?

Ever consider dropping the anti-d's for a bit?

Courtney · #4 (**permalink**) May 21, 05

I dont know about physically but it will mess you up mentally for sure..because anti depressants fuck with the opiats that produce seratonin and e releases all of it so for a week after you'll be really depressed

Niko · #5 (**permalink**) May 21, 05

The Desyrel(Trazodone) doesn't have any known direct interactions with MDMA and it's class of substances. However, scientists don't really understand why Trazodone works, so there are no guarantees that it won't react with you. So it doesn't look like it could be dangerous unless you combine a lot of both.

Wellbutrin(Bupropion) commonly interacts with MDMA, however, and can alter the effects unpredictably (more or less nausea, more or less serotonin, higher/lower succeptability to dehydration), though not typically the intensity. Once again, there's no guarantee interactions wouldn't occur, but there doesn't seem to be any hugely serious contraindictions.

My Advice: If you're going to do it, plan on doing no more than 1 cap. Have a friend who has done a decent amount of E get it from someone he knows and trusts, and get him/her to take it no less than 1 hour before you to make sure it's not funky.

Disclaimer: This information was gathered on Erowid, Google (RX drug information sites), and by my own knowledge with antianxiety and antidepressant drugs, and E.

Aspectre · #6 (**permalink**) May 21, 05

This reminds me... I was going to ask this a long time ago
When I was first getting into e, I was on Prozac, and I had been for the whole year before that...
My first 3 or 4 times popping I had taken prozac the day I popped, then I stopped taking the prozac (and still havn't since)

What is the potential damage it could have done to me?
or maybe has?

decypher · #7 (**permalink**) May 21, 05

Everytime there is a massive, all the ravers flock to FNK day of to ask E questions lol. EVERYTIME

Niko · #8 (**permalink**) May 21, 05

^Yes. And in the spirit of not having any of them carried out of the Coliseum on stretchers, I answer them.

sinnerman · #9 (**permalink**) May 21, 05

^^^

Niko has good info, but I think you should be more cautious.

Trazodone and bupropion do not fall into any of the three main antidepressant groups (tricyclics, MAOIs & SSRIs). Their modes of action are unique (& consequently reciprocally magnifying). Because of this, I'd advise against using ecstasy (within 2 weeks of taking this prescription combo), as you may be at a much higher risk of developing serotonin syndrome. Effectively, that's an ecstasy overdose (although it can happen because of any drug acting on serotonin).

Since your brain is already forced to deal with two antidepressants & your depression, it's probably totally maxed out trying to maintain a balance of serotonin; even half a pill might be too much for it can handle right now. Also, neither of these antidepressants will reduce neurotoxicity like an SSRI would; in combination they will likely increase it.

Serotonin syndrome is very rare but also very serious, and I'd imagine that you (if anyone) are at a much higer risk. Read some stuff: http://www.nmsis.org/Related_Syndromes.shtml

P.S.
Which other antidepressants have you tried previously? I wonder why your doctor has prescribed this combo without first trying an SSRI.

Sue Bitch · #10 (**permalink**) May 21, 05

while i was takin antidepressants and E i felt like nothing different happened. Bu then after a while i felt that the anti depressants were just a placipo and heance why i no longer an taking them *yeah me!*

sinnerman · #11 (**permalink**) May 22, 05

Quote:

Originally Posted by decypher

SSRI's have different effects. google it or read up on erowid.org or something.

Brupropion is not an SSRI; it's in an antidepressant class of its own. In fact, of all the antidepressants Brupropion has the least inhibitory effect on serotonin reuptake pathways. Instead, brupropion competes with serotonin for the same receptors.

Therefore, it's very likely that bruproprion will considerably intensify the effects of ecstasy and seriously increase the risks mentioned in my last post.
Knowledge is power; power is hot.

decypher · #12 (**permalink**) May 22, 05

My bad, i just assumed, i dont have time anymore to search the interweb for pharmacology facts that i'm never gonna use except to look good on a webforum. Hence why i told this person to look it up instead of relaying on other people.

Niko · #13 (**permalink**) May 23, 05

Quote:

Originally Posted by sinnerman

Therefore, it's very likely that bruproprion will considerably intensify the effects of ecstasy and seriously increase the risks mentioned in my last post.

Erowid claims that while Brupropion can alter the effects of E in a variety of ways, intensity does not seem to be one of those.

gratia · #14 (**permalink**) May 28, 05

Quote:

Originally Posted by decypher

My bad, i just assumed, i dont have time anymore to search the interweb for pharmacology facts that i'm never gonna use except to look good on a webforum. Hence why i told this person to look it up instead of relaying on other people.

so...first of all......i have extensively researched it on my thank you ;) but i didn't find a whole lot cause these are very rare perscriptions to be on especially for depression...so i thought i would call on the help of my fellow fnkers to get some advice. fuck...i don't even know why i am on antidepressants. i fricken hate it. for some screwed up reason i would rather fry my brain out. but i guess that is how messed up i am. anyway...i think i will actually be smart about this one....it sounds too dangerous to me. pretty sketchy mixture. but thanks to those who sent me helpful replies with solid information. i am glad you guys care ;)

baby-phat · #15 (**permalink**) May 28, 05

I was taking wellbutrin and celexa for a while (a year or so) and only did E a total of 3 times during the period. I never experienced any nasty or ill effects. But that was just me, and everyone's body reacts differently to things. Just thought I'd share my experience. :)

BTW- I was too lazy to read the whole thread. hehe

*jess* · #16 (**permalink**) May 29, 05

I have heard that some people say "E doesn't work" while on anti-depressants while it works just fine for others.

My suggestions...make sure you are safe and with friends, and skip your meds within an 8 hour period to minimize any interactions.

onefour · #17 (**permalink**) Jun 03, 05

Quote:

Originally Posted by 420-Crook

This reminds me... I was going to ask this a long time ago
When I was first getting into e, I was on Prozac, and I had been for the whole year before that...
My first 3 or 4 times popping I had taken prozac the day I popped, then I stopped taking the prozac (and still havn't since)

What is the potential damage it could have done to me?
or maybe has?

prozak actually prevents you from depleteting your seratonin completely and from oxidation happening in your brain so your better off then i am thast for sure lol

onefour · #18 (**permalink**) Jun 03, 05

Quote:

Originally Posted by Tinkerbell

I have heard that some people say "E doesn't work" while on anti-depressants while it works just fine for others.

My suggestions...make sure you are safe and with friends, and skip your meds within an 8 hour period to minimize any interactions.

atni depressents use the transmittors that the serratonin uses, so if u pop an anti depressent before e, you wont get the effects of the mdma, but THEORETICALLY if you pop them after you peak it prevents loss of seratonin and the oxidation process. but i could be wrong so dont listen to me lol

http://dancesafe.org/slideshow/ <- read this